środa, 11 maja 2011
środa, 4 maja 2011
Drug Profile: Clenbuterol
Clenbuterol 0,04
Generic name: Clenbuterol Hydrochloride
pack: 100 tablets 0,04mg/tabl
Active Life: Up to 68 hours
Drug Class: Beta-2-symphatonimetric, thermalgenic(Oral)
Average Dose: Men 100-140 mcg/day...... Women 80-100 mcg/day
Acne: No
Water Retention: No
High Blood Pressure: Sometimes
Liver Toxic: Unknown
Aromatization: None
Strong Thermogenic
Clenbuterol is a widely used bronchodilator in many parts of the world. The drug is most often prepared in 20mcg tablets, but it is also available in syrup and injectable form. Clenbuterol belongs to a broad group of drugs knows as sympathomimetics. These drugs affect that sympathetic nervous system in a wide number of ways, largely mediated by the distribution of adrenoceptors. There are actually nine different types of these receptors in the body, which are classified as either alpha or beta and further subcategorized by type number. Depending on the specific affinities of these agents for the various receptors, they can potentially be used in the treatment of conditions such as asthma, hypertension, cardiovascular shock, arrhythmias, migraine headaches and anaphylactic shock. The text Goodman and Gillman's The Pharmacological Basis of Therapeutics Edition does a good job of describing the diverse nature in which these drugs affect the body:
`Most of the actions of catecholamines and sympathomimetic agents can be classified into seven broad types: (1) peripheral excitatory action on certain types of smooth muscles such as those in blood vessels supplying the skin, kidney, and mucous membranes, and on the gland cells, such as those of the salivary and sweat glands; (2) a peripheral inhibitory action on certain other types of smooth muscle, such as those in the wall of the gut, in the bronchial tree, and in blood vessels supplying skeletal muscle; (3) a cardiac excitatory action, responsible for in increase in heart rate and force of contraction; (4) metabolic actions, such as an increase in the rate of glycogenolysis in liver and muscle and liberation of free fatty acids from adipose tissue; (5) endocrine actions, such as modulation of the secretion of insulin, rennin, and pituitary hormones; (6) CNS actions, such as respiratory stimulation and, with some of the drugs, an increase in wakefulness and psychomotor activity and a reduction in appetite; and (7) presynaptic actions that result in either inhibition or facilitation of the release of the neurotransmitters such as such as norepinephrine and acetylcholine."
The drug clenbuterol is specifically a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of beta-receptors. Of particular interest is the fact that this drug has little beta-1 stimulating activity. Since beta-1 receptors are closely tied to the cardiac effects of these agents, this allows clenbuterol to reduce reversible airway obstruction (and effect of beta-2 stimulation) with much less cardiovascular side effects compared to nonselective beta agonists. Clinical studies with this drug show it is extremely effective as a bronchodilator, with a low level of user complaints and high patient compliance. Clenbuterol also exhibits an extremely long half-life in the body, which is measured to be approximately 34 hours. This makes steady blood levels easy to achieve, requiring only a single or twice daily dosing schedule at most. This of course makes it much easier for the patient to use, and may tie in to its high compliance rate. In spite that clenbuterol is available in a wide number of other countries however; this compound has never been approved for use in the United States. The fact that there are a number of similar, effective asthma medications already available in this country may have something to do with this, as a prospective drug firm would likely not find it a profitable enough product to warrant undergoing the expense of the FDA approval process. Regardless, foreign clenbuterol preparations are widely available on the U.S. black market.
In animal studies, clenbuterol is shown to exhibit anabolic activity, so it is obviously an attractive trait to the athlete. This compound is additionally a known thermogenic, with beta-2 agonists like clenbuterol shown to directly stimulate fat cells and accelerate the breakdown of triglycerides to form free fatty acids. Its efficacy in this area makes clenbuterol a very attractive, and today almost mandatory, pre-contest drug. Those interested in this drug are most often hoping it will impart a little of both benefits, promoting the loss of body fat while imparting strength and muscle mass increases. But as was well pointed out by a review published in the August 1995 issue of Medicine and Science in Sports and Exercise, the possible anabolic activities in humans are very questionable, and based only on animal data using much larger doses than would be required for bronchodilation. With such reports there has been a lot of debate lately as to whether or not clenbuterol is really anabolic at all. Some seem to swear by the fact that it builds muscle regardless, firmly sticking by "clen" as a great off-season or adjunct anabolic. To others such reports are confirmation that athletes have wasted valuable time and money on drugs that do not work as they are intended to by the user. This debate continues today, with many still using clenbuterol as a potential anabolic. With this in mind athletes will tailor their dosage and cycling of this product individually depending on which of the two "possible" results are more desired, and how much side effects are to be tolerated. The possible side effects of clenbuterol include those of other CNS stimulants, and include such occurrences as shaky hands, insomnia, sweating, increased blood pressure and nausea. These side effects will generally subside after a week or so of use however, once the user becomes accustomed to the drug. One would typically start a cycle by gradually increasing the dosage each day until a desired range is established. This process will minimize the unwanted side effects seen from the drug; which otherwise might be dramatic if a large dose is administered from the onset. Men generally end up in the range of 2-8 tablets per day, although some people do claim to tolerate even higher dosages. Women get by on less, generally 2-4 tablets daily. Very quickly, the drug will elevate the body temperature. The rise is not usually dramatic, perhaps a half of a Cegree or so, sometimes a little more. This elevation is due to your body burning excess energy (largely from fat) and is usually not uncomfortable. Now that it is working, the number of consecutive days clenbuterol can be used is believed to be dependent on the goal of the individual. To be clear, the athletic benefits of this drug will only last for a limited time and then diminish, largely due to beta-receptor down regulation. When using it for fat loss. the primary effect of the drug, it seems to work well for approximately 4-6 weeks. During this period users will want to constantly monitor their body temperature. We are assured clenbuterol is working by the temperature elevation. Once the temperature drops back to normal, clenbuterol is no longer exhibiting a thermogenic effect. At this point increasing the dosage would not be very effective, and a break for at least a few weeks should be taken before it is used again effectively. If one is looking for strength gains, clenbuterol appears to be effective for a much shorter period of time, around 3-4 weeks. This may be due to an absence of real anabolic effect, with the strength gain seen with clenbuterol possibly due only to the stimulant properties of the drug (similar to the strength boost seen by Ephedrine users). Again however, this is still debated.
Many competitors also find the fat burning effect of clenbuterol can be further enhanced by additional substances. When combined with thyroid hormones, specifically the powerful CytomelŽ, the thermogenic effect can become extremely dramatic. This can be to a point that the athlete could shred exceptional amounts of extra fat during contest preparations, without a dramatic restriction in calories. Such a mix can be further used during a steroid cycle, eliciting a much harder look from the anabolics. These cutting agents can often greatly inhibit extra fat storage during the cycle, even when using strong aromatizing androgens. A clenbuterol/thyroid mix is also common when using growth hormone, further enhancing the thermogenic and anabolic effect of this therapy.
Generic name: Clenbuterol Hydrochloride
pack: 100 tablets 0,04mg/tabl
Active Life: Up to 68 hours
Drug Class: Beta-2-symphatonimetric, thermalgenic(Oral)
Average Dose: Men 100-140 mcg/day...... Women 80-100 mcg/day
Acne: No
Water Retention: No
High Blood Pressure: Sometimes
Liver Toxic: Unknown
Aromatization: None
Strong Thermogenic
Clenbuterol is a widely used bronchodilator in many parts of the world. The drug is most often prepared in 20mcg tablets, but it is also available in syrup and injectable form. Clenbuterol belongs to a broad group of drugs knows as sympathomimetics. These drugs affect that sympathetic nervous system in a wide number of ways, largely mediated by the distribution of adrenoceptors. There are actually nine different types of these receptors in the body, which are classified as either alpha or beta and further subcategorized by type number. Depending on the specific affinities of these agents for the various receptors, they can potentially be used in the treatment of conditions such as asthma, hypertension, cardiovascular shock, arrhythmias, migraine headaches and anaphylactic shock. The text Goodman and Gillman's The Pharmacological Basis of Therapeutics Edition does a good job of describing the diverse nature in which these drugs affect the body:`Most of the actions of catecholamines and sympathomimetic agents can be classified into seven broad types: (1) peripheral excitatory action on certain types of smooth muscles such as those in blood vessels supplying the skin, kidney, and mucous membranes, and on the gland cells, such as those of the salivary and sweat glands; (2) a peripheral inhibitory action on certain other types of smooth muscle, such as those in the wall of the gut, in the bronchial tree, and in blood vessels supplying skeletal muscle; (3) a cardiac excitatory action, responsible for in increase in heart rate and force of contraction; (4) metabolic actions, such as an increase in the rate of glycogenolysis in liver and muscle and liberation of free fatty acids from adipose tissue; (5) endocrine actions, such as modulation of the secretion of insulin, rennin, and pituitary hormones; (6) CNS actions, such as respiratory stimulation and, with some of the drugs, an increase in wakefulness and psychomotor activity and a reduction in appetite; and (7) presynaptic actions that result in either inhibition or facilitation of the release of the neurotransmitters such as such as norepinephrine and acetylcholine."
The drug clenbuterol is specifically a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of beta-receptors. Of particular interest is the fact that this drug has little beta-1 stimulating activity. Since beta-1 receptors are closely tied to the cardiac effects of these agents, this allows clenbuterol to reduce reversible airway obstruction (and effect of beta-2 stimulation) with much less cardiovascular side effects compared to nonselective beta agonists. Clinical studies with this drug show it is extremely effective as a bronchodilator, with a low level of user complaints and high patient compliance. Clenbuterol also exhibits an extremely long half-life in the body, which is measured to be approximately 34 hours. This makes steady blood levels easy to achieve, requiring only a single or twice daily dosing schedule at most. This of course makes it much easier for the patient to use, and may tie in to its high compliance rate. In spite that clenbuterol is available in a wide number of other countries however; this compound has never been approved for use in the United States. The fact that there are a number of similar, effective asthma medications already available in this country may have something to do with this, as a prospective drug firm would likely not find it a profitable enough product to warrant undergoing the expense of the FDA approval process. Regardless, foreign clenbuterol preparations are widely available on the U.S. black market.
In animal studies, clenbuterol is shown to exhibit anabolic activity, so it is obviously an attractive trait to the athlete. This compound is additionally a known thermogenic, with beta-2 agonists like clenbuterol shown to directly stimulate fat cells and accelerate the breakdown of triglycerides to form free fatty acids. Its efficacy in this area makes clenbuterol a very attractive, and today almost mandatory, pre-contest drug. Those interested in this drug are most often hoping it will impart a little of both benefits, promoting the loss of body fat while imparting strength and muscle mass increases. But as was well pointed out by a review published in the August 1995 issue of Medicine and Science in Sports and Exercise, the possible anabolic activities in humans are very questionable, and based only on animal data using much larger doses than would be required for bronchodilation. With such reports there has been a lot of debate lately as to whether or not clenbuterol is really anabolic at all. Some seem to swear by the fact that it builds muscle regardless, firmly sticking by "clen" as a great off-season or adjunct anabolic. To others such reports are confirmation that athletes have wasted valuable time and money on drugs that do not work as they are intended to by the user. This debate continues today, with many still using clenbuterol as a potential anabolic. With this in mind athletes will tailor their dosage and cycling of this product individually depending on which of the two "possible" results are more desired, and how much side effects are to be tolerated. The possible side effects of clenbuterol include those of other CNS stimulants, and include such occurrences as shaky hands, insomnia, sweating, increased blood pressure and nausea. These side effects will generally subside after a week or so of use however, once the user becomes accustomed to the drug. One would typically start a cycle by gradually increasing the dosage each day until a desired range is established. This process will minimize the unwanted side effects seen from the drug; which otherwise might be dramatic if a large dose is administered from the onset. Men generally end up in the range of 2-8 tablets per day, although some people do claim to tolerate even higher dosages. Women get by on less, generally 2-4 tablets daily. Very quickly, the drug will elevate the body temperature. The rise is not usually dramatic, perhaps a half of a Cegree or so, sometimes a little more. This elevation is due to your body burning excess energy (largely from fat) and is usually not uncomfortable. Now that it is working, the number of consecutive days clenbuterol can be used is believed to be dependent on the goal of the individual. To be clear, the athletic benefits of this drug will only last for a limited time and then diminish, largely due to beta-receptor down regulation. When using it for fat loss. the primary effect of the drug, it seems to work well for approximately 4-6 weeks. During this period users will want to constantly monitor their body temperature. We are assured clenbuterol is working by the temperature elevation. Once the temperature drops back to normal, clenbuterol is no longer exhibiting a thermogenic effect. At this point increasing the dosage would not be very effective, and a break for at least a few weeks should be taken before it is used again effectively. If one is looking for strength gains, clenbuterol appears to be effective for a much shorter period of time, around 3-4 weeks. This may be due to an absence of real anabolic effect, with the strength gain seen with clenbuterol possibly due only to the stimulant properties of the drug (similar to the strength boost seen by Ephedrine users). Again however, this is still debated.
Many competitors also find the fat burning effect of clenbuterol can be further enhanced by additional substances. When combined with thyroid hormones, specifically the powerful CytomelŽ, the thermogenic effect can become extremely dramatic. This can be to a point that the athlete could shred exceptional amounts of extra fat during contest preparations, without a dramatic restriction in calories. Such a mix can be further used during a steroid cycle, eliciting a much harder look from the anabolics. These cutting agents can often greatly inhibit extra fat storage during the cycle, even when using strong aromatizing androgens. A clenbuterol/thyroid mix is also common when using growth hormone, further enhancing the thermogenic and anabolic effect of this therapy.
środa, 27 kwietnia 2011
Drug Profile: Mesterolone
Generic name: Mesterolone
Common Name: Mesterolone, PureProviron, Proviron
Active Life: 8-12 hours (effects last about 24 hours)
Drug Class: Androgenic Steroid/Anti- Aromatization (Oral)
Average Dose: Men 25-100 mg/day.....Women 25-50 mg/day
Acne: Rare
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: Low
Aromatization: None
DHT Conversion: No, it is a derivative of DHT
Decrease HPTA function: No
PureProviron is brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes PureProviron is primarily used as an anti-estrogen. It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to PureArimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to PureNolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced.
The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.
This drug is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol (PureStan), oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. PureProviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the
potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).
The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug is often used throughout the entire cycle. As mentioned earlier, it is often combined with PureNolvadex (tamoxifen citrate) or PureClomid (clomiphene citrate) when heavily estrogenic steroids are being taken (PureDbol, testosterone etc.). Administering 50mg of PureProviron and 20mg PureNolvadex daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.
Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a "safe" oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on PurePrimo (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.
The popularity of Proviron amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Proviron is now very easy to obtain on the black market. Most versions will be manufactured by UG Labs, and should cost about $1-$2 per 25 mg tab. This drug is packaged in both push-through strips and pouches, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex, Letrozole, or Aromasin ares actually also a good choice. These drugs were designed specifically as an anti-aromatase too.
Common Name: Mesterolone, PureProviron, Proviron
Active Life: 8-12 hours (effects last about 24 hours)
Drug Class: Androgenic Steroid/Anti- Aromatization (Oral)
Average Dose: Men 25-100 mg/day.....Women 25-50 mg/day
Acne: Rare
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: Low
Aromatization: None
DHT Conversion: No, it is a derivative of DHT
Decrease HPTA function: No
PureProviron is brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes PureProviron is primarily used as an anti-estrogen. It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to PureArimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to PureNolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced.The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.
This drug is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol (PureStan), oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. PureProviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the
potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug is often used throughout the entire cycle. As mentioned earlier, it is often combined with PureNolvadex (tamoxifen citrate) or PureClomid (clomiphene citrate) when heavily estrogenic steroids are being taken (PureDbol, testosterone etc.). Administering 50mg of PureProviron and 20mg PureNolvadex daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.
Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a "safe" oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on PurePrimo (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.
The popularity of Proviron amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Proviron is now very easy to obtain on the black market. Most versions will be manufactured by UG Labs, and should cost about $1-$2 per 25 mg tab. This drug is packaged in both push-through strips and pouches, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex, Letrozole, or Aromasin ares actually also a good choice. These drugs were designed specifically as an anti-aromatase too.
poniedziałek, 25 kwietnia 2011
Drug Profile: Dromastanolone Dipropionate
Generic name: Dromastanolone Dipropionate
Common Name: Masta, Drostanoxen, Mastonex
Active Life: 2-3 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 300-500 mg/week
Acne: Yes
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: None
DHT Conversion: No, it is a DHT derivative
Decrease HPTA function: Yes
Other Info: Highly androgenic/moderately anabolic/moderate anti-estogenic
Masteron (Drostanoxen 100) is an injectable preparation containing the steroid drostanolone propionate. Drostanolone is a derivative of dihydrotestosterone, most specifically 2alpha-methyldihydrotestosterone. As a result, the structure of this steroid is that of a moderate anabolic/potent androgen which does not aromatize to estrogen. Water retention and gynecomastia therefore do not come into play with this drug. Masteron may in fact exhibit anti-estrogenic activity in the body, competing with other substrates for binding to aromatase. This would reduce the conversion rate of other steroids, Masteron acting in the same way as the oral steroid PureProviron.
Bodybuilders have a strong like for non-aromatizing androgens, and find Drostanoxen very useful in a cutting phase. It is generally used for a number of weeks prior to a competition, in an effort to bring out an improved look of density and hardness to the muscles. As long as body fat percentage is low enough, Masteron should work very well. Provided everything fits as if should, the user can achieve that "ripped" look so popular to professional bodybuilding. The androgenic effect can also be crucial during this period, a time when caloric intake is drastically lowered. The user is provided added "kick" or "drive" to push through the grueling training sessions leading up to the show. Recreational users might also be interested in Masteron. Although dihydrotestosterone is not highly active in muscle tissue, the 2 alkylation present on drostanolone considerably intensifies its anabolic effect. It can therefore be used somewhat effectively as bulking agent, providing a consistent gain of high quality muscle mass. It can also be successfully combined with other steroids for an enhanced effect. Mixing drostanolone with an injectable anabolic such as Deca-Durabolin or Equipoise can prove quite useful for example, the two providing notably enhanced muscle gain without excessive water retention. For greater mass gains, a stronger androgen such as PureDbol or an injectable testosterone would do the trick. The result here can be an extreme muscle gain, with a lower level of water retention & other estrogenic side effects than if these steroids were used alone (usually in higher doses). Masteron could of course be used during cutting phases of training as well. A cycle of this drug combined with Winstrol, Primobolan or Oxandrolone should provide great muscle retention and fat loss, during a period which can be very catabolic without steroids. It is an added benefit that none of these steroids aromatize, and therefore there is no additional worry of unwanted water and fat retention.
Since the propionate ester is used with this compound, injections need to be repeated at least every 3 or 4 days in order to maintain a consistent level of hormone in the blood. The weekly dosage is in the range of 300-500mg.
Since estrogen is not an issue, side effects are generally mild with this steroid. As discussed earlier, gynecomastia, water retention, and high blood pressureare not a problem. Masteron is also not liver toxic, so there is little concern stress will be placed on this organ, even during longer cycles. The only real side effects would be from the basic androgenic properties of dihydrotestosterone. These includes oily skin, acne, body/facial hair growth, aggression and accelerated hair loss. Since this compound is already a synthetic DHT, Proscar would have no impact on the level of androgenic effects. Men with a receding hairline or those with a predisposition for baldness may therefore wish to stay away from Masteron completely, as the potent androgenic effect of this steroid can easily accelerate this condition.
Common Name: Masta, Drostanoxen, Mastonex
Active Life: 2-3 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 300-500 mg/week
Acne: Yes
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: None
DHT Conversion: No, it is a DHT derivative
Decrease HPTA function: Yes
Other Info: Highly androgenic/moderately anabolic/moderate anti-estogenic
Masteron (Drostanoxen 100) is an injectable preparation containing the steroid drostanolone propionate. Drostanolone is a derivative of dihydrotestosterone, most specifically 2alpha-methyldihydrotestosterone. As a result, the structure of this steroid is that of a moderate anabolic/potent androgen which does not aromatize to estrogen. Water retention and gynecomastia therefore do not come into play with this drug. Masteron may in fact exhibit anti-estrogenic activity in the body, competing with other substrates for binding to aromatase. This would reduce the conversion rate of other steroids, Masteron acting in the same way as the oral steroid PureProviron.
Bodybuilders have a strong like for non-aromatizing androgens, and find Drostanoxen very useful in a cutting phase. It is generally used for a number of weeks prior to a competition, in an effort to bring out an improved look of density and hardness to the muscles. As long as body fat percentage is low enough, Masteron should work very well. Provided everything fits as if should, the user can achieve that "ripped" look so popular to professional bodybuilding. The androgenic effect can also be crucial during this period, a time when caloric intake is drastically lowered. The user is provided added "kick" or "drive" to push through the grueling training sessions leading up to the show. Recreational users might also be interested in Masteron. Although dihydrotestosterone is not highly active in muscle tissue, the 2 alkylation present on drostanolone considerably intensifies its anabolic effect. It can therefore be used somewhat effectively as bulking agent, providing a consistent gain of high quality muscle mass. It can also be successfully combined with other steroids for an enhanced effect. Mixing drostanolone with an injectable anabolic such as Deca-Durabolin or Equipoise can prove quite useful for example, the two providing notably enhanced muscle gain without excessive water retention. For greater mass gains, a stronger androgen such as PureDbol or an injectable testosterone would do the trick. The result here can be an extreme muscle gain, with a lower level of water retention & other estrogenic side effects than if these steroids were used alone (usually in higher doses). Masteron could of course be used during cutting phases of training as well. A cycle of this drug combined with Winstrol, Primobolan or Oxandrolone should provide great muscle retention and fat loss, during a period which can be very catabolic without steroids. It is an added benefit that none of these steroids aromatize, and therefore there is no additional worry of unwanted water and fat retention.Since the propionate ester is used with this compound, injections need to be repeated at least every 3 or 4 days in order to maintain a consistent level of hormone in the blood. The weekly dosage is in the range of 300-500mg.
Since estrogen is not an issue, side effects are generally mild with this steroid. As discussed earlier, gynecomastia, water retention, and high blood pressureare not a problem. Masteron is also not liver toxic, so there is little concern stress will be placed on this organ, even during longer cycles. The only real side effects would be from the basic androgenic properties of dihydrotestosterone. These includes oily skin, acne, body/facial hair growth, aggression and accelerated hair loss. Since this compound is already a synthetic DHT, Proscar would have no impact on the level of androgenic effects. Men with a receding hairline or those with a predisposition for baldness may therefore wish to stay away from Masteron completely, as the potent androgenic effect of this steroid can easily accelerate this condition.
sobota, 23 kwietnia 2011
Drug Profile: Boldenone Undecylenate
Generic name: Boldenone Undecylenate
Common Name: Bold, PureEQ, Boldenone, EQ, Boldex
Active Life: 14-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 400-600 mg/week......Women 50-150 mg/week
Acne: Rare
Water Retention: Low
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: Some, about 50% less than testosterone
DHT Conversion: Low
Decrease HPTA function: Moderate
Boldenone (Equiposie or PureEQ) is a derivative of testosterone, which exhibits strong anabolic and moderately androgenic properties. The undecylenate ester greatly extends the activity of the drug (the undecylenate ester is only one carbon atom longer than decanoate), so that clinically injections would need to be repeated every three or four weeks. In the veterinary feild Equipoise is most commonly used on horses, exhibiting a pronounced effect on lean bodyweight, appetite and general disposition of the animal. As with all steroids, this compound shows a marked ability for increasing red blood cell production. In recent years this compound has become a favorite among athletes. Many consider it an ideal replacement to Deca-Durabolin a.k.a PureDeca
The side effects of Equipoise are generally mild. The structure of boldenone does allow it to convert into estrogen, but it does not have an extremely high affinity to do so. If we look at aromatization studies, they suggest that its rate of estrogen conversion should be about half that of testosterone's. Water retention with this drug would therefore be slightly higher than that with Deca-Durabolin (with an estimated 20% conversion), but much less than we would find with a stronger compound as Testosterone. While there is still a chance of encountering an estrogen related side effect as such when using Equipoise, problems are usually not encountered at a moderate dosage level. Gynecomastia might become a problem, but usually only with very sensitive individuals or (again) with those using higher dosages. If estrogenic effects become a problem, the addition of Nolvadex should of course make the cycle more tolerable. An anti-aromatase such as PureArimidex, Femara, or PureLetrozole would be a stronger option, however probably not necessary with such a mild drug.
Although typically dosage related, Equipoise can also produce distinct androgenic side effects. Oily skin, acne, increased aggression and hair loss are all possible with this compound. Women find this drug quite comfortable, virilization symptoms usually unheard of when taken at low doses. Boldenone does reduce to a more potent androgen (dihydroboldenone) via the 5alpha reductase enzyme (which produces DHT from testosterone), however its affinity for this interaction in the human body is low to nonexistent. Therefore the reductase inhibitor Proscar would not be of much use with Equipoise, as it would be blocking what is at best an insignificant path of metabolism for the steroid. Although this drug is relatively mild, it still has a depressive effect on endogenous testosterone levels, therefore a proper post cycle therapy HCG and PureClomid/Nolvadex is needed at the conclusion of each cycle to avoid a "crash". A waiting time of around 3 weeks is required before starting PCT, enabling enough of the drug to clear one's system to make PCT effective.
In order to maintain stable blood levels, PureEQ should be injected at least once per week. It is most commonly used at a dosage of 400-600mg per week for men, 50-150 mg per week for women.
Equipoise is not a rapid mass builder, but will provide a slow but steady gain of strength and quality muscle mass. The most positive effects of this drug are seen when it is used for longer cycles, usually lasting at least 10 weeks in length. The muscle gained should not be the smooth bulk seen with androgens, but instead a very defined and solid look. Since water bloat is not contributing greatly to the diameter of the muscle, much of the size gained on a cycle of Equipoise can be retained after the drug has been discontinued. It is interesting to note that structurally Equipoise and the classic bulking drug Dianabol are almost identical. In the case of Equipoise the compound uses a l7beta ester (undecylenate), while PureDbol is 17 alpha alkylated. Aside from that difference, the drugs are basically the same. Of course they act quite differently in the body, which goes to show the 17-methylation effects more than just the oral efficancy of a steroid.
As discussed earlier, Equipoise is a very versatile compound. We can create a number of drug combinations with it depending on the desired result. For mass, one may want to stack it with Anadrol or an injectable testosterone. The result should be an incredible gain of muscle size and strength, without the same intensity of side effects if using the androgen (at a higher dose) alone. When used in a cutting cycle, muscle hardness and density can be greatly improved when combining Equipoise with a non-aromatizable steroid such as trenbolone acetate, Halotestin, or Winstrol. For some however, even the low buildup of estrogen associated with this compound is enough to relegate its use to bulking cycles only.
Boldenone is not an ideal steroid for the drug tested athlete however. This drug has the tendency to produce detectable metabolites in the urine months after use, a worry most commonly associated with Deca-Durabolin. This is of course due to the high oil solubility of long chain esterified injectable steroids, a property which enables the drug to remain deposited in fatty tissues for extended periods of time. While this will reliably slow the release of steroid into the blood stream, it also allows small residual amounts to remain present in the body far after the initial injection. The release of stubborn stores of hormone would no doubt also be enhanced around contest time, a period when the athlete drastically attempts to mobilize unwanted body fat. If enough were used in the off-season, the athlete may actually fail a drug screen for boldenone although many months may have past since the drug was last injected.
Common Name: Bold, PureEQ, Boldenone, EQ, Boldex
Active Life: 14-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 400-600 mg/week......Women 50-150 mg/week
Acne: Rare
Water Retention: Low
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: Some, about 50% less than testosterone
DHT Conversion: Low
Decrease HPTA function: Moderate
Boldenone (Equiposie or PureEQ) is a derivative of testosterone, which exhibits strong anabolic and moderately androgenic properties. The undecylenate ester greatly extends the activity of the drug (the undecylenate ester is only one carbon atom longer than decanoate), so that clinically injections would need to be repeated every three or four weeks. In the veterinary feild Equipoise is most commonly used on horses, exhibiting a pronounced effect on lean bodyweight, appetite and general disposition of the animal. As with all steroids, this compound shows a marked ability for increasing red blood cell production. In recent years this compound has become a favorite among athletes. Many consider it an ideal replacement to Deca-Durabolin a.k.a PureDeca
The side effects of Equipoise are generally mild. The structure of boldenone does allow it to convert into estrogen, but it does not have an extremely high affinity to do so. If we look at aromatization studies, they suggest that its rate of estrogen conversion should be about half that of testosterone's. Water retention with this drug would therefore be slightly higher than that with Deca-Durabolin (with an estimated 20% conversion), but much less than we would find with a stronger compound as Testosterone. While there is still a chance of encountering an estrogen related side effect as such when using Equipoise, problems are usually not encountered at a moderate dosage level. Gynecomastia might become a problem, but usually only with very sensitive individuals or (again) with those using higher dosages. If estrogenic effects become a problem, the addition of Nolvadex should of course make the cycle more tolerable. An anti-aromatase such as PureArimidex, Femara, or PureLetrozole would be a stronger option, however probably not necessary with such a mild drug.
Although typically dosage related, Equipoise can also produce distinct androgenic side effects. Oily skin, acne, increased aggression and hair loss are all possible with this compound. Women find this drug quite comfortable, virilization symptoms usually unheard of when taken at low doses. Boldenone does reduce to a more potent androgen (dihydroboldenone) via the 5alpha reductase enzyme (which produces DHT from testosterone), however its affinity for this interaction in the human body is low to nonexistent. Therefore the reductase inhibitor Proscar would not be of much use with Equipoise, as it would be blocking what is at best an insignificant path of metabolism for the steroid. Although this drug is relatively mild, it still has a depressive effect on endogenous testosterone levels, therefore a proper post cycle therapy HCG and PureClomid/Nolvadex is needed at the conclusion of each cycle to avoid a "crash". A waiting time of around 3 weeks is required before starting PCT, enabling enough of the drug to clear one's system to make PCT effective.
In order to maintain stable blood levels, PureEQ should be injected at least once per week. It is most commonly used at a dosage of 400-600mg per week for men, 50-150 mg per week for women.
Equipoise is not a rapid mass builder, but will provide a slow but steady gain of strength and quality muscle mass. The most positive effects of this drug are seen when it is used for longer cycles, usually lasting at least 10 weeks in length. The muscle gained should not be the smooth bulk seen with androgens, but instead a very defined and solid look. Since water bloat is not contributing greatly to the diameter of the muscle, much of the size gained on a cycle of Equipoise can be retained after the drug has been discontinued. It is interesting to note that structurally Equipoise and the classic bulking drug Dianabol are almost identical. In the case of Equipoise the compound uses a l7beta ester (undecylenate), while PureDbol is 17 alpha alkylated. Aside from that difference, the drugs are basically the same. Of course they act quite differently in the body, which goes to show the 17-methylation effects more than just the oral efficancy of a steroid.
As discussed earlier, Equipoise is a very versatile compound. We can create a number of drug combinations with it depending on the desired result. For mass, one may want to stack it with Anadrol or an injectable testosterone. The result should be an incredible gain of muscle size and strength, without the same intensity of side effects if using the androgen (at a higher dose) alone. When used in a cutting cycle, muscle hardness and density can be greatly improved when combining Equipoise with a non-aromatizable steroid such as trenbolone acetate, Halotestin, or Winstrol. For some however, even the low buildup of estrogen associated with this compound is enough to relegate its use to bulking cycles only.
Boldenone is not an ideal steroid for the drug tested athlete however. This drug has the tendency to produce detectable metabolites in the urine months after use, a worry most commonly associated with Deca-Durabolin. This is of course due to the high oil solubility of long chain esterified injectable steroids, a property which enables the drug to remain deposited in fatty tissues for extended periods of time. While this will reliably slow the release of steroid into the blood stream, it also allows small residual amounts to remain present in the body far after the initial injection. The release of stubborn stores of hormone would no doubt also be enhanced around contest time, a period when the athlete drastically attempts to mobilize unwanted body fat. If enough were used in the off-season, the athlete may actually fail a drug screen for boldenone although many months may have past since the drug was last injected.
poniedziałek, 18 kwietnia 2011
T3 Theories and Observations
i never used it without GH for that long except once or twice, of course it worked nowhere near as good as it did in conjunction with GH.,
i had tried it the usualy pyramid up to high dose as quick as possible, stay there then tapered down after 8-12 weeks while dieting with really good results once... so im not just talking out of my ass supporting longer cycles with a more moderate dose with no experience about short cycles.
i found even though i didnt suffer any real bad rebound(none that i couldnt attribute to mainly my diet getting way loose after cutting hard) nor did i see anylong term supression from the short cycles, i definitely felt suppressed for at least a month or two and my body temp was much lower.
i also have had friends who did the usual high dose short cycle thing under the assumption that staying on for a short period and using a dose higher than normal or a dose that puts the levels above HIGH NATURAL levels in the body, the theory was flawed and they suffered supresson basically at least for as long as they were on in many cases. ,
RESULTS OF THE TYPICAL HIGHER DOSE TAPER CYCLE
IMO and in theirs it wasnt worth it, especially since real strict dieting usually results in slacking off when you come off the diet, so coming off of a diet AND off of t3 is a bad idea for maintaining results. plus, any technique that you can use for fat loss or to maintain fat loss such as dieting stricter, lowering cals/carbs, or increasing cardio/training to increase your fat burning naturally, every one of those techniques also negatively influence thyroid output or recovery.
LONGER, LOW/MODERATE DOSE USE
without GH, id probably either use bloodwork to monitor thyroid output during dieting and just use exogenous t3 as a way to keep my thyroid at optimal levels when the diet starts to slow down natural production. i know this is the way alot of contest prep gurus suggest, and many experienced pros. if you dont want to do the whole bloodwork thing, your best bet is to take your temp every morning at the same time for a couple weeks before you start dieting as a baseline to get an avg. temp per week, and then keep taking it ED when you start your diet.
when you start seeing a consistent temp decrease ED over a week or so, its a good bet that your body is reacting to the diet trying to do the homeostasis thing, and you could benefit from adding t3 n increments of 12.5-25mcg of t3 per day and seeing how that affects your temp results boosting them back near normal.
id say 25mcg to start, then if you dont see results after 7-14 days as far as fat burning slow down start pickng up at least, or an increase to your morning body temp, then add another tab of t3 per week until you do. even the largest pro's that do this say that you shouldnt need more than 50-75mcg MAX.
LOW/MODERATE DOSE RESULTS
there are HUGE benefitsto this method IMO.
this seems much more effective and safe in regards to staying on it for a longer period. if you are simply adding enough t3 to keep your body in optimal range as it fights to stay the same as part of your training and diet regime, IMO coming off will be much much less painful and the results of coming off will be minor or neglible even perhaps, as long as you keep your diet very clean, i would imagine even if it was after a show, an increase in CLEAN cals plus some gugguls/iodine and other thryroid support supps would help your bodies natural thyroid output recover as quick as possible.
that is my observation from personal results of both methods as well as what have seen with others, regarding the low/moderate dosages in regards to using anywhere from 2-6 months without gh, and even up to 10 months or so in conjunction with 3-6iu gh per day.
if your not going to have your thyroid levels tested often while on it trying to stay in optimal normal levels, AT LEAST have them tested before, and then 4-8 weeks AFTER you cease using t3 and/or dieting. id take my temp ED as well, if anything using it as a guideline to decide when to get my levels checked.. if my morning temp is rising consistently for a few weeks after i come off, or if they are at or close to my pre diet temperature in relation to how much my temp dropped while dieting when i was dieting, then i know that levels are probably back or close to 100% and its time to get the bloodwork to know for sure.
on the other hand, if my temp is still noticeably lower than pre diet levels, or as low or lower than my AM temp was prior to adding low dose replacement t3 to my diet, its a sign im not recovering, and its time to get bloodwork done to see what is up and how low they are.
if they are still low, i dont know of how much you could do to encourage recovery except for some support supps and more time off.
HOWEVER, continuing to restrict calories, as well as overtraining will have definite effects on your thyroid levels. these factors can inhibit thyroid output even if you hadnt used exogenous thyroid meds, so you may want to alter these variables if you are not recovering. a MODERATE increase in CLEAN calories, adding a piece or two of fruit, and a decrease in training volume and intensity after a very intense period of training and dieting even after using t3 should help your natural levels recover.
WHY HIGHER DOSE SHORT CYCLES FAIL FOR ANYTHING BUT TEMPORARY RESULTS
you really need to remember these factors and not be afraid to gain a lb or two of fat and water after you come off, you cant stay in contest shape forever, and like stated before, even in a non t3 assisted diet, when getting VERY lean, the intensity of your dieting and training will negatively effect thyroid output as your body fights the change to stay in homeostasis.
by staying SUPER strict, ie very low carbs low fat or low anything, or continuing to do high levels of cardio ie 2 a day sessions on top of your weight training etc, you may be doing yourself more harm then good in the long run, at the minimum keep lifting intensely, but reduce your cardio and increase your cals slightly to support your thyroid recovery.
many guys do crazy shit like even increasing their cardio or calorie restrictions after coming off of t3 in an attempt to keep every last lb of fat and water they lost off of their bodies... all this achieves is continuing to supress your thyroid levels regardless of coming off IMO.
HERE IS MY THEORY ON WHY SHORT BURST PYRAMID T3 CYCLES SUCK, AND WHY LONGER LOW DOSE IS BETTER
IMO if you keep cals SUPER clean but let them increase to maintenance at least, and decrease the cardio but keep the lifting intense, you better your chances of natural levels recovering as quickly as possible, AND ALSO by lifting intensely doing everything you can by keeping as much of the weight you do regain as muscle, you cant stay super lean forever, but you CAN eat and train in a way that supports body recomposition as favorably towards muscle as possible.
dont forget, the biggest boost to your metabolism is your muscle mass and increasing it... that is another reason why i think longer lower dose t3 cycles are FAR more optimal to the old pyramid up, pyramid down high dose brief cycles that you see everywhere, lasting anywhere from 4-10 weeks.
low/moderate dose t3 may have a positive effect on metabolism and muscle building, but when using doses that put you way out of the natural optimum levels, you are simply increasing your metabolism to a point that you need to eat extra protein and cals to stave off the muscle loss.
logically, if you are using t3 in dosages that put your levels way over normal range, you are simply making up for a shitty innefficient diet, either due to inexperience or just laziness and RELYING on the drug for fat loss, instead of using it as an adjunct to a proper diet and training.
for someone inexperienced in thyroid use, compare it to gear use. take 2 guys of similar genetics, and both are using the same types of gear, say test and tren or something basic but effective.
SHORTCUT VS LONG TERM COMPARISON
bber #1 has an impeccable work ethic, trains hard and intensely but also efficiently and intelligently to avoid overtraining. he also follows a good well rounded bbing diet, rarely misses meals, and although he enjoys himself and will have some drinks with his buds and party or get drunk every blue moon, he mostly makes sure he is well rested to ensure proper recovery. most importantly #1 does all these important things that build lean muscle CONSISTENTLY and both on or off cycle.
bber#1 uses a base of test, moderate dose of 400mg tren E or para. he may use an oral or fast acting drug to kick start his cycle for couple weeks or a month, and then use a fast acting drug towards the end of his cycle with proper PCT when he comes off, or uses an HRT dose as a bridge
bber #2 goes through the motions at the gym, when he is on he trains balls to the wall sometimes every day for 1.5-2hrs a day cuz his cycles enable him to feel like superman and his strenght stays up and he doesnt fatigue anywhere near as fast as he does when clean, and following his more is better philosophy, he trains each bodypart until he "feels" its time to stop, and trains them up to 2x a week when he is on cycle and feels this is better. however he is quick to burnout, even while on a heavy cycle, and starts missing workouts.
#2 is the same way with dieting, goes to the extreme over does everything, but isnt consistent. he also doesnt eat near as clean, he gains alot of water/fat weight when he is on, gets burnt out and either starts dieting or simply skipping meals soon after he bulks, never being able to stick to one or the other for 6-8 weeks. he still makes great gains and can look just as good as bber #1 sometimes and can hang with him in the gym when they are on cycle.
#2 will run 1g of test per week minimum, with at least 100mg of tren ace per day or an equal dose of longer acting tren per week. he will throw in orals, dbol/anadrol, anything that gives him immediate results to kick start his cycle, even if the results on the scale and in the gym as far as weights are simply a temporary boost from increased in water, even if its intramuscular mostly and he still looks good.
also, if his gains slow or come to a halt, he simply ups the dose, adds more gear, or throws the orals back in.
his training and diet, while sometimes very dedicated, even to the point of being counterproductive, are very inconsistent. he looks to drugs as the main source of gains or lack thereof and never really sits back to look at the big picture and never figures out that its his lack of a consistent schedule/diet, and inadequate rest, and too much partying.
even tho bber #2 also makes incredible gains when he is on cycle, he looks to drugs as the be all and end all, cause of and solution to results and/or lack.
#2 thinks every bber that is pro or even bigger than him either has better genetics, and/or is on higher doses and other drugs and combos that he cant afford or believes he just doesnt know about.
now lets say both bbers at the peak of their cycles are in very similar condition, almost exact as far as mass/leanness...
which bber do you believe will have the most success at maintaining or bettering their peak or near peak condition year round whether or not they are at the peak of their cycle, or are simply off or on an HRT replacement dose.
anyways, if u look at my example, IMO it VERY relates to a bber using t3. if you have to use a dose of T3 that pushes your levels way past the upper normal limits, you are using it as a crutch to either A)make up for a diet and/or training that is severly lacking, or B) your trying to lose too much fat too fast.
in the case of A, if you need higher doses of t3 to achieve a level of leanness you couldnt approach otherwise, you are really setting yourslf up for a big dissapointment. IF YOU CANT GET NEAR THAT CONDITION WITH NO OR LOW TO MODERATE T3 USE, HOW ARE YOU GOING TO MAINTAIN ANYTHING CLOSE TO THAT WHEN YOU COME OFF, EVEN IF YOUR LEVELS RECOVER AS FAST AS POSSIBLE?? YOU CANT!
so IMO low/moderate use, though best used as short as possible, even if u need to use it longer cuz you have more fat to lose, it is MUCH more optimal to do it this way as far as maintaining or even gaining some muscle while getting to the desired body composition. plus you will be n a much better.
Short term higher doses could be used if your really impatient and out of shape and want to get lean as fast as possible, but pretty much unless you are just looking for temporary results it is a waste, and though you might not gain EVERYTHING back, any results are much harder to maintain.
i had tried it the usualy pyramid up to high dose as quick as possible, stay there then tapered down after 8-12 weeks while dieting with really good results once... so im not just talking out of my ass supporting longer cycles with a more moderate dose with no experience about short cycles.
i found even though i didnt suffer any real bad rebound(none that i couldnt attribute to mainly my diet getting way loose after cutting hard) nor did i see anylong term supression from the short cycles, i definitely felt suppressed for at least a month or two and my body temp was much lower.
i also have had friends who did the usual high dose short cycle thing under the assumption that staying on for a short period and using a dose higher than normal or a dose that puts the levels above HIGH NATURAL levels in the body, the theory was flawed and they suffered supresson basically at least for as long as they were on in many cases. ,
RESULTS OF THE TYPICAL HIGHER DOSE TAPER CYCLE
IMO and in theirs it wasnt worth it, especially since real strict dieting usually results in slacking off when you come off the diet, so coming off of a diet AND off of t3 is a bad idea for maintaining results. plus, any technique that you can use for fat loss or to maintain fat loss such as dieting stricter, lowering cals/carbs, or increasing cardio/training to increase your fat burning naturally, every one of those techniques also negatively influence thyroid output or recovery.
LONGER, LOW/MODERATE DOSE USE
without GH, id probably either use bloodwork to monitor thyroid output during dieting and just use exogenous t3 as a way to keep my thyroid at optimal levels when the diet starts to slow down natural production. i know this is the way alot of contest prep gurus suggest, and many experienced pros. if you dont want to do the whole bloodwork thing, your best bet is to take your temp every morning at the same time for a couple weeks before you start dieting as a baseline to get an avg. temp per week, and then keep taking it ED when you start your diet.
when you start seeing a consistent temp decrease ED over a week or so, its a good bet that your body is reacting to the diet trying to do the homeostasis thing, and you could benefit from adding t3 n increments of 12.5-25mcg of t3 per day and seeing how that affects your temp results boosting them back near normal.
id say 25mcg to start, then if you dont see results after 7-14 days as far as fat burning slow down start pickng up at least, or an increase to your morning body temp, then add another tab of t3 per week until you do. even the largest pro's that do this say that you shouldnt need more than 50-75mcg MAX.
LOW/MODERATE DOSE RESULTS
there are HUGE benefitsto this method IMO.
this seems much more effective and safe in regards to staying on it for a longer period. if you are simply adding enough t3 to keep your body in optimal range as it fights to stay the same as part of your training and diet regime, IMO coming off will be much much less painful and the results of coming off will be minor or neglible even perhaps, as long as you keep your diet very clean, i would imagine even if it was after a show, an increase in CLEAN cals plus some gugguls/iodine and other thryroid support supps would help your bodies natural thyroid output recover as quick as possible.
that is my observation from personal results of both methods as well as what have seen with others, regarding the low/moderate dosages in regards to using anywhere from 2-6 months without gh, and even up to 10 months or so in conjunction with 3-6iu gh per day.
if your not going to have your thyroid levels tested often while on it trying to stay in optimal normal levels, AT LEAST have them tested before, and then 4-8 weeks AFTER you cease using t3 and/or dieting. id take my temp ED as well, if anything using it as a guideline to decide when to get my levels checked.. if my morning temp is rising consistently for a few weeks after i come off, or if they are at or close to my pre diet temperature in relation to how much my temp dropped while dieting when i was dieting, then i know that levels are probably back or close to 100% and its time to get the bloodwork to know for sure.
on the other hand, if my temp is still noticeably lower than pre diet levels, or as low or lower than my AM temp was prior to adding low dose replacement t3 to my diet, its a sign im not recovering, and its time to get bloodwork done to see what is up and how low they are.
if they are still low, i dont know of how much you could do to encourage recovery except for some support supps and more time off.
HOWEVER, continuing to restrict calories, as well as overtraining will have definite effects on your thyroid levels. these factors can inhibit thyroid output even if you hadnt used exogenous thyroid meds, so you may want to alter these variables if you are not recovering. a MODERATE increase in CLEAN calories, adding a piece or two of fruit, and a decrease in training volume and intensity after a very intense period of training and dieting even after using t3 should help your natural levels recover.
WHY HIGHER DOSE SHORT CYCLES FAIL FOR ANYTHING BUT TEMPORARY RESULTS
you really need to remember these factors and not be afraid to gain a lb or two of fat and water after you come off, you cant stay in contest shape forever, and like stated before, even in a non t3 assisted diet, when getting VERY lean, the intensity of your dieting and training will negatively effect thyroid output as your body fights the change to stay in homeostasis.
by staying SUPER strict, ie very low carbs low fat or low anything, or continuing to do high levels of cardio ie 2 a day sessions on top of your weight training etc, you may be doing yourself more harm then good in the long run, at the minimum keep lifting intensely, but reduce your cardio and increase your cals slightly to support your thyroid recovery.
many guys do crazy shit like even increasing their cardio or calorie restrictions after coming off of t3 in an attempt to keep every last lb of fat and water they lost off of their bodies... all this achieves is continuing to supress your thyroid levels regardless of coming off IMO.
HERE IS MY THEORY ON WHY SHORT BURST PYRAMID T3 CYCLES SUCK, AND WHY LONGER LOW DOSE IS BETTER
IMO if you keep cals SUPER clean but let them increase to maintenance at least, and decrease the cardio but keep the lifting intense, you better your chances of natural levels recovering as quickly as possible, AND ALSO by lifting intensely doing everything you can by keeping as much of the weight you do regain as muscle, you cant stay super lean forever, but you CAN eat and train in a way that supports body recomposition as favorably towards muscle as possible.
dont forget, the biggest boost to your metabolism is your muscle mass and increasing it... that is another reason why i think longer lower dose t3 cycles are FAR more optimal to the old pyramid up, pyramid down high dose brief cycles that you see everywhere, lasting anywhere from 4-10 weeks.
low/moderate dose t3 may have a positive effect on metabolism and muscle building, but when using doses that put you way out of the natural optimum levels, you are simply increasing your metabolism to a point that you need to eat extra protein and cals to stave off the muscle loss.
logically, if you are using t3 in dosages that put your levels way over normal range, you are simply making up for a shitty innefficient diet, either due to inexperience or just laziness and RELYING on the drug for fat loss, instead of using it as an adjunct to a proper diet and training.
for someone inexperienced in thyroid use, compare it to gear use. take 2 guys of similar genetics, and both are using the same types of gear, say test and tren or something basic but effective.
SHORTCUT VS LONG TERM COMPARISON
bber #1 has an impeccable work ethic, trains hard and intensely but also efficiently and intelligently to avoid overtraining. he also follows a good well rounded bbing diet, rarely misses meals, and although he enjoys himself and will have some drinks with his buds and party or get drunk every blue moon, he mostly makes sure he is well rested to ensure proper recovery. most importantly #1 does all these important things that build lean muscle CONSISTENTLY and both on or off cycle.
bber#1 uses a base of test, moderate dose of 400mg tren E or para. he may use an oral or fast acting drug to kick start his cycle for couple weeks or a month, and then use a fast acting drug towards the end of his cycle with proper PCT when he comes off, or uses an HRT dose as a bridge
bber #2 goes through the motions at the gym, when he is on he trains balls to the wall sometimes every day for 1.5-2hrs a day cuz his cycles enable him to feel like superman and his strenght stays up and he doesnt fatigue anywhere near as fast as he does when clean, and following his more is better philosophy, he trains each bodypart until he "feels" its time to stop, and trains them up to 2x a week when he is on cycle and feels this is better. however he is quick to burnout, even while on a heavy cycle, and starts missing workouts.
#2 is the same way with dieting, goes to the extreme over does everything, but isnt consistent. he also doesnt eat near as clean, he gains alot of water/fat weight when he is on, gets burnt out and either starts dieting or simply skipping meals soon after he bulks, never being able to stick to one or the other for 6-8 weeks. he still makes great gains and can look just as good as bber #1 sometimes and can hang with him in the gym when they are on cycle.
#2 will run 1g of test per week minimum, with at least 100mg of tren ace per day or an equal dose of longer acting tren per week. he will throw in orals, dbol/anadrol, anything that gives him immediate results to kick start his cycle, even if the results on the scale and in the gym as far as weights are simply a temporary boost from increased in water, even if its intramuscular mostly and he still looks good.
also, if his gains slow or come to a halt, he simply ups the dose, adds more gear, or throws the orals back in.
his training and diet, while sometimes very dedicated, even to the point of being counterproductive, are very inconsistent. he looks to drugs as the main source of gains or lack thereof and never really sits back to look at the big picture and never figures out that its his lack of a consistent schedule/diet, and inadequate rest, and too much partying.
even tho bber #2 also makes incredible gains when he is on cycle, he looks to drugs as the be all and end all, cause of and solution to results and/or lack.
#2 thinks every bber that is pro or even bigger than him either has better genetics, and/or is on higher doses and other drugs and combos that he cant afford or believes he just doesnt know about.
now lets say both bbers at the peak of their cycles are in very similar condition, almost exact as far as mass/leanness...
which bber do you believe will have the most success at maintaining or bettering their peak or near peak condition year round whether or not they are at the peak of their cycle, or are simply off or on an HRT replacement dose.
anyways, if u look at my example, IMO it VERY relates to a bber using t3. if you have to use a dose of T3 that pushes your levels way past the upper normal limits, you are using it as a crutch to either A)make up for a diet and/or training that is severly lacking, or B) your trying to lose too much fat too fast.
in the case of A, if you need higher doses of t3 to achieve a level of leanness you couldnt approach otherwise, you are really setting yourslf up for a big dissapointment. IF YOU CANT GET NEAR THAT CONDITION WITH NO OR LOW TO MODERATE T3 USE, HOW ARE YOU GOING TO MAINTAIN ANYTHING CLOSE TO THAT WHEN YOU COME OFF, EVEN IF YOUR LEVELS RECOVER AS FAST AS POSSIBLE?? YOU CANT!
so IMO low/moderate use, though best used as short as possible, even if u need to use it longer cuz you have more fat to lose, it is MUCH more optimal to do it this way as far as maintaining or even gaining some muscle while getting to the desired body composition. plus you will be n a much better.
Short term higher doses could be used if your really impatient and out of shape and want to get lean as fast as possible, but pretty much unless you are just looking for temporary results it is a waste, and though you might not gain EVERYTHING back, any results are much harder to maintain.
niedziela, 17 kwietnia 2011
Drug Profile: Testosterone Enanthate
Generic name: Testosterone Enanthate
Jelfa S.A., Poland
(pharmacy production)
pack: 5 vials a 1ml 100mg/ml
Active Life: 15-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 250-1000 mg/week
Acne: Yes
Water Retention: Yes, high
High Blood Pressure: Yes
Liver Toxic: Low, except in mega dosages
Aromatization: Yes, high
DHT Conversion: Yes, high
Decrease HPTA function: Yes, severe
Testosterone enanthate is an oil based injectable steroid, designed to slowly release testosterone from the injection site (depot). Once administered, serum concentrations of this hormone will rise for several days, and remain markedly elevated for approximately two weeks. It may actually take three weeks for the action of this drug to fully diminish. For medical purposes this is the most widely prescribed testosterone, used regularly to treat cases of hypogonadism and other disorders related to androgen deficiency. Since patients generally do not selfadminister such injections, a long acting steroid like this is a very welcome item. Therapy is clearly more comfortable in comparison to an ester like propionate, which requires a much more frequent dosage schedule.
Testosterone is a powerful hormone with notably prominent side effects. Much of which stem from the fact that testosterone exhibits a high tendency to convert into estrogen. Related side effects may therefore become a problem during a cycle. For starters, water retention can become quite noticeable. This can produce a clear loss of muscle definition, as subcutaneous fluids begin to build. The storage of excess body fat may further reduce the visibility of muscle features, another common problem with aromatizing steroids. The excess estrogen level during/after your cycle also has the potential to lead up to gynecomastia. Adding an ancillary drug like Nolvadex and/or Proviron is therefore advisable to those with a known sensitivity to this side effect. The anti-aromatase Arimidex, Femara, or Aromasin are a much better choices though. It is believed that the use of an anti-estrogen can slightly lower the anabolic effect of most androgen cycles (estrogen and water weight are often thought to facilitate strength and muscle gain), so one might want to see if such drugs are actually necessary before committing to use. A little puffiness under the nipple is a sign that gynecomastia is developing. If this is left to further develop into pronounced swelling, soreness and the growth of small lumps under the nipples, some form of action should be taken immediately to treat it (obviously quitting the drug or adding ancillaries like Nolvadex).
Being a testosterone product, all the standard androgenic side effects are also to be expected. Oily skin, acne, aggressiveness, facial/body hair growth and male pattern baldness are all possible. Older or more sensitive individuals might therefore choose to avoid testosterone products, and look toward milder anabolics like DecaDurabolin or Equipoise which produce fewer side effects. Others may opt to add the drug Proscar/Propecia, which will minimize the conversion of testosterone into DHT (dihydrotestosterone). With blood levels of this metabolite notably reduced, the impact of related side effects should also be reduced. With strong bulking drugs however, the user will generally expect to incur strong side effects and will often just tolerate them. Most athletes really do not find the testosterones all that uncomfortable (especially in the face of the end result), as can be seen with the great popularity of such compounds.
Although this particular ester is active for a much longer duration, most prefer to inject it on a weekly or bi-weekly basis in order to keep blood levels stable. The usual dosage would be in the range of 250mg-750mg a week. This level is quite sufficient, and should provide the user a rapid gain of strength and body weight. Above this level estrogenic side effects will no doubt become much more pronounced, possibly outweighing any new muscle gained. Those looking for greater bulk would be better served by adding an oral like Anadrol or Dianabol, combinations which prove to work great. If one wishes to use a testosterone yet retain a level of quality and definition to the physique, an injectable anabolic like DecaDurabolin or Equipoise may prove to be a better choice. Here we can use a lower dosage of enanthate, so as to gain an acceptable amount of muscle but keep the buildup of estrogen to a minimum.
With the proper administration of ancillary drugs, Nolva/Clomid and HCG, during post cycle recovery, much of the new muscle mass can be retained for a long time after the cycle has been stopped.
Jelfa S.A., Poland
(pharmacy production)
pack: 5 vials a 1ml 100mg/ml
Active Life: 15-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 250-1000 mg/week
Acne: Yes
Water Retention: Yes, high
High Blood Pressure: Yes
Liver Toxic: Low, except in mega dosages
Aromatization: Yes, high
DHT Conversion: Yes, high
Decrease HPTA function: Yes, severe
Testosterone enanthate is an oil based injectable steroid, designed to slowly release testosterone from the injection site (depot). Once administered, serum concentrations of this hormone will rise for several days, and remain markedly elevated for approximately two weeks. It may actually take three weeks for the action of this drug to fully diminish. For medical purposes this is the most widely prescribed testosterone, used regularly to treat cases of hypogonadism and other disorders related to androgen deficiency. Since patients generally do not selfadminister such injections, a long acting steroid like this is a very welcome item. Therapy is clearly more comfortable in comparison to an ester like propionate, which requires a much more frequent dosage schedule.
Testosterone is a powerful hormone with notably prominent side effects. Much of which stem from the fact that testosterone exhibits a high tendency to convert into estrogen. Related side effects may therefore become a problem during a cycle. For starters, water retention can become quite noticeable. This can produce a clear loss of muscle definition, as subcutaneous fluids begin to build. The storage of excess body fat may further reduce the visibility of muscle features, another common problem with aromatizing steroids. The excess estrogen level during/after your cycle also has the potential to lead up to gynecomastia. Adding an ancillary drug like Nolvadex and/or Proviron is therefore advisable to those with a known sensitivity to this side effect. The anti-aromatase Arimidex, Femara, or Aromasin are a much better choices though. It is believed that the use of an anti-estrogen can slightly lower the anabolic effect of most androgen cycles (estrogen and water weight are often thought to facilitate strength and muscle gain), so one might want to see if such drugs are actually necessary before committing to use. A little puffiness under the nipple is a sign that gynecomastia is developing. If this is left to further develop into pronounced swelling, soreness and the growth of small lumps under the nipples, some form of action should be taken immediately to treat it (obviously quitting the drug or adding ancillaries like Nolvadex).
Being a testosterone product, all the standard androgenic side effects are also to be expected. Oily skin, acne, aggressiveness, facial/body hair growth and male pattern baldness are all possible. Older or more sensitive individuals might therefore choose to avoid testosterone products, and look toward milder anabolics like DecaDurabolin or Equipoise which produce fewer side effects. Others may opt to add the drug Proscar/Propecia, which will minimize the conversion of testosterone into DHT (dihydrotestosterone). With blood levels of this metabolite notably reduced, the impact of related side effects should also be reduced. With strong bulking drugs however, the user will generally expect to incur strong side effects and will often just tolerate them. Most athletes really do not find the testosterones all that uncomfortable (especially in the face of the end result), as can be seen with the great popularity of such compounds.
Although this particular ester is active for a much longer duration, most prefer to inject it on a weekly or bi-weekly basis in order to keep blood levels stable. The usual dosage would be in the range of 250mg-750mg a week. This level is quite sufficient, and should provide the user a rapid gain of strength and body weight. Above this level estrogenic side effects will no doubt become much more pronounced, possibly outweighing any new muscle gained. Those looking for greater bulk would be better served by adding an oral like Anadrol or Dianabol, combinations which prove to work great. If one wishes to use a testosterone yet retain a level of quality and definition to the physique, an injectable anabolic like DecaDurabolin or Equipoise may prove to be a better choice. Here we can use a lower dosage of enanthate, so as to gain an acceptable amount of muscle but keep the buildup of estrogen to a minimum.
With the proper administration of ancillary drugs, Nolva/Clomid and HCG, during post cycle recovery, much of the new muscle mass can be retained for a long time after the cycle has been stopped.
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